Endocrine Abstracts

Introduction: Paragangliomas/pheochromocytomas present frequently with vague symptomatology which makes its diagnosis difficult and challenging. Cuantification of fractionated metanephrines and fractionated catecholamines in 24 h urine sample are used for diagnosis. There are situationes that can produce false positive results such as stress, drugs or smoking that must be taken into account.Patients and methods: Retrospective study on the requests made f...

Introduction: The NETTER 1 trial resulted in markedly longer progression-free survival (PFS), with preliminary evidence of an overall survival benefit. We report the results of PFS and safety of (177Lu)-DOTATATE in patients treated in our hospital between 2014 and 2016.Methods: Transversal and descriptive study of seven patients with advanced, progressive, somatostatin receptor-positive tumors who had received previous treatments. All of them were treate...

Introduction: Stroke is the second cause of death in the world and the first cause of disability. It is also the second cause of Diabetes-related death. The success of reperfusion therapies is time-dependent, with most delays being patient-related. We investigated the response to stroke in diabetic patients (DM), as their risk of stroke is increased by 1,8-6 times.Material and Methods: Consecutive patients with acute stroke or transient ischemic attack w...

Introduction: Gestational diabetes mellitus (GDM) is associated with an increase of maternal-fetal complications. Continuous glucose monitoring system (CGMS) detects postprandial hyperglycemia and hypoglycemia during 24 h.Methods: Women with GDM in gestational weeks 26–32 were allocated a CGMS (IproTM2) after diagnosis in an observational prospective study. It was analysed:- CGMS: Mean glucose and standard deviation...

Introduction: Rapid correction of hyponatremia is known to cause central pontine myelinolysis. It may concurrently involve other areas of brain as well, referred as extra-pontine myelinolysis (EPM). Isolated EPM however is a very rare occurrence. We present a case of EPM where the hyponatremia was secondary to syndrome of inappropriate antidiuretic hormone secretion (SIADH) after surgery for a pituitary macroadenoma.Case report: A 36-year-old man underwe...

Introduction: Non-functioning pituitary adenomas (NFPAs) represent the most common pituitary tumour. They usually appear in the middle age of life, without differences between genders. Mass growth produces the first symptoms so the diagnosis is usually late. Surgery is the first-line treatment with variable success (19-83%). The objective of this study is to evaluate the symptoms, diagnosis, treatment and final state of patients with NFPAs.Methods: Obser...

Abstract: A 14-yr-old male patient with acromegaly and TSH-induced hyperthyroidism is reported. He was referred for hormonal study due to clinical suspicion of acromegaly. Physical examination showed acromegalic/gigantism features (high stature: 194.5 cm (P>90), such as: abnormal growth of the hands and feet, furrowed forehead and pronounced brow ridge). No goiter was found. GH levels were high and were not suppressed after oral glucose (GH: 12.50 ng/ml, GH after ...

Introduction: The duration of hypercortisolism in Cushing’s disease (CD) appears to be inversely related to the reversibility of complications, which in turn increase mortality. This makes it necessary to identify medical therapies capable of normalizing cortisol overproduction before transsphenoidal surgery. The aim of this study was to determine if the clinical data of patients with CD before surgery allow predicting the presence and/or abundance of somatostatin (ssts) ...

Objective: The diagnosis of central hypoadrenalism (HPAI) is a major clinical challenge. The gold standard procedure remains insuline tolerance test (ITT). Liquid chromatography tandem mass spectrometry (LC-MS/MS) is considered the best procedure for the evaluation of cortisol levels. This study aimed to evaluate cut-offs of serum (TM-SeC) and salivary cortisol (SaC) by LC-MS/MS and serum cortisol by ECLIA assay (E-SeC) after Standard dose ACTH test (SDCT) in diagnosing HPAI.<...

Background: The short-term follow-up of patients with differentiated thyroid cancer (DTC) after the initial treatment is based on the measurement of stimulated thyroglobulin (s-Tg) and the use of diagnostic whole body scan (WBS).Objective: To evaluate the clinical utility of WBS performed at 6–12 months after thyroidectomy. Examine the correlation between s-Tg and results of WBS.Methods: We retrospectively evaluated all patien...